Sclerostin antibody (AA 130-210)

Catalog No. ABIN8124552

The Rabbit Polyclonal anti-Sclerostin antibody is suitable to detect Sclerostin in samples from Human, Mouse and Rat. It has been validated for WB, IHC and ELISA.

Quick Overview for Sclerostin antibody (AA 130-210) (ABIN8124552)

Target: Sclerostin (SOST)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sclerostin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Sclerostin Antibody

Binding Specificity: AA 130-210

Purpose: Sclerostin Antibody

Specificity: Sclerostin Polyclonal Antibody detects endogenous levels of Sclerostin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Sclerostin . at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Sclerostin

Target: Sclerostin (SOST)

Alternative Name: Sclerostin

Background:

Synonyms: SOST, Sclerostin

Background: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],

Gene Name: SOST

Protein Name: Sclerostin

Gene ID: 50964

UniProt: Q9BQB4