STK38L antibody (AA 380-460)

Catalog No. ABIN8124614

This Rabbit Polyclonal antibody specifically detects STK38L in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STK38L antibody (AA 380-460) (ABIN8124614)

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK38L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-STK38L Antibody

Binding Specificity: AA 380-460

Purpose: NDR2 Antibody

Specificity: NDR2 Polyclonal Antibody detects endogenous levels of NDR2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from NDR2 . at AA range: 380-460

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for STK38L

Target: STK38L (serine/threonine Kinase 38 Like (STK38L))

Alternative Name: NDR2

Background:

Synonyms: STK38L, KIAA0965, NDR2, Serine/threonine-protein kinase 38-like, NDR2 protein kinase, Nuclear Dbf2-related kinase 2

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.,function:Involved in the regulation of structural processes in differentiating and mature neuronal cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Associated with the actin cytoskeleton.,subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,

Gene Name: STK38L

Protein Name: Serine/threonine-protein kinase 38-like

Gene ID: 23012

UniProt: Q9Y2H1