STIP1 antibody (AA 250-300)

Catalog No. ABIN8124986

This Rabbit Polyclonal antibody specifically detects STIP1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STIP1 antibody (AA 250-300) (ABIN8124986)

Target: STIP1 (Stress-Induced-phosphoprotein 1 (STIP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-STIP1 Antibody

Binding Specificity: AA 250-300

Purpose: STIP1/HOP Antibody

Specificity: This antibody detects endogenous levels of STIP1/HOP at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human STIP1/HOP AA range: 250-300

Isotype: IgG

Application Details

Application Notes: IHC1:50-200 ,WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for STIP1

Target: STIP1 (Stress-Induced-phosphoprotein 1 (STIP1))

Alternative Name: STIP1/HOP

Background:

Synonyms: Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

Background: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A, MIM 140550) and HSP90 (see HSP90AA1, MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009],

Gene Name: STIP1

Protein Name: STIP1/HOP

Gene ID: 10963

UniProt: P31948