FGFRL1 antibody (AA 231-330)

Catalog No. ABIN761681

The Rabbit Polyclonal anti-FGFRL1 antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect FGFRL1 in samples from Human.

Quick Overview for FGFRL1 antibody (AA 231-330) (ABIN761681)

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFRL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FGFRL1 Antibody

Binding Specificity: AA 231-330

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FGFR5/FGFRL1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FGFRL1

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Alternative Name: Fgfr5

Background:

Synonyms: FGF homologous factor receptor, FGF receptor like protein 1, FGFR 5, FGFR like protein, FGFR5, FGFRL1, FHFR, Fibroblast growth factor receptor 5, Fibroblast growth factor receptor like 1, FGRL1_HUMAN.

Background: FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found.

Gene ID: 53834

Pathways: RTK Signaling