TCL1A antibody (AA 30-110)

Catalog No. ABIN8125089

The Rabbit Polyclonal anti-TCL1A antibody is suitable to detect TCL1A in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for TCL1A antibody (AA 30-110) (ABIN8125089)

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCL1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TCL1A Antibody

Binding Specificity: AA 30-110

Purpose: Tcl1 Antibody

Specificity: The antibody detects endogenous Tcl1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TCL1A

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Alternative Name: Tcl1

Background:

Synonyms: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)

Background: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],

Gene Name: TCL1A TCL1

Protein Name: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)

Gene ID: 8115

UniProt: P56279

Pathways: Stem Cell Maintenance