Thyroperoxidase antibody (AA 600-700)

Catalog No. ABIN8125211

This Mouse Monoclonal antibody specifically detects Thyroperoxidase in WB, IHC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for Thyroperoxidase antibody (AA 600-700) (ABIN8125211)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: AB1601

Product Details anti-Thyroperoxidase Antibody

Binding Specificity: AA 600-700

Purpose: Thyroid Peroxidase (TPO) mouse mAb

Specificity: This antibody detects endogenous levels of TPO protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human Thyroid Peroxidase protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:1000 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid Peroxidase

Background:

Synonyms: Thyroid peroxidase,TPO,

Background: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Gene Name: TPO

Protein Name: Thyroid Peroxidase (TPO)

Gene ID: 3662

UniProt: P07202

Pathways: Thyroid Hormone Synthesis