TFE3 antibody (AA 100-200)

Catalog No. ABIN8125277

This Mouse Monoclonal antibody specifically detects TFE3 in WB, ELISA, IHC, IF and IP. It exhibits reactivity toward Human, Mouse and Cow.

Quick Overview for TFE3 antibody (AA 100-200) (ABIN8125277)

Target: TFE3 (Transcription Factor E3 (TFE3))

Reactivity: Human, Mouse, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFE3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: AB2352

Product Details anti-TFE3 Antibody

Binding Specificity: AA 100-200

Purpose: TFE3 mouse mAb

Specificity: This antibody detects endogenous levels of TFE3 protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 100 - 200 of the human TFE3 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:1000 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. | IP, 0. 5 μg-1:4 μg antibody for 200 μg-1:400 μg extracts of whole cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Alternative Name: TFE3

Background:

Synonyms: Transcription factor E3, Class E basic helix-loop-helix protein 33 (bHLHe33) , BHLHE33, TFE3

Background: transcription factor binding to IGHM enhancer 3 (TFE3) Homo sapiens This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma) , NONO (non-POU domain containing, octamer-binding) , and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1) , among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Gene Name: TFE3

Protein Name: TFE3

Gene ID: 7030

UniProt: P19532