TTF1 antibody (AA 50-150)

Catalog No. ABIN8125283

This Mouse Monoclonal antibody specifically detects TTF1 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for TTF1 antibody (AA 50-150) (ABIN8125283)

Target: TTF1 (Transcription Termination Factor, RNA Polymerase I (TTF1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: AB1381

Product Details anti-TTF1 Antibody

Binding Specificity: AA 50-150

Purpose: TTF1 mouse mAb

Specificity: The antibody can specifically recognize human TTF1 protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 50 - 150 of the human TTF1 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:50-1:200 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for TTF1

Target: TTF1 (Transcription Termination Factor, RNA Polymerase I (TTF1))

Alternative Name: TTF1

Background:

Synonyms: AV026640, BCH, Benign chorea, BHC, Homeobox protein NK 2 homolog A, Homeobox protein NK-2 homolog A, Homeobox protein Nkx 2. 1, Homeobox protein Nkx-2. 1, Homeobox protein Nkx2. 1, NK 2, NK 2 homolog A, NK2, NK2 homeobox 1, NK2, drosophila, homolog of, A, NK2. 1, Mouse, homolog of, Nkx 2 1, NKX 2. 1, NKX 2A, NKX2 1, Nkx2-1, NKX2. 1, NKX21_HUMAN, NKX2A, T EBP, T/EBP, TEBP, Thyroid nuclear factor 1, Thyroid nuclear factor, Thyroid specific enhancer binding protein, Thyroid transcription factor 1, Tin man, Tinman, TITF 1, TITF1, TTF 1, TTF-1, TTF1

Background: Thyroid transcription factor 1 (TTF-1) is a nuclear protein with a molecular weight of 38-40 kDa. It is the basic material for thyroid differentiation and the regulation of thyroglobulin secretion. It can promote the transport of thyroid peroxidase and iodine / sodium. TTF-1 is mainly distributed in type II alveolar epithelium, respiratory epithelium and Clara cells of thyroid and lung in adult tissues, but it is not expressed in type I alveolar epithelium. It is mainly used for the diagnosis of small cell lung cancer, the differential diagnosis of primary lung adenocarcinoma from metastatic adenocarcinoma, and the differential diagnosis of lung cancer from malignant mesothelioma and paraganglioma of pleura.

Gene Name: NKX2-1

Protein Name: TTF1

Gene ID: 7080

UniProt: P43699

Pathways: Thyroid Hormone Synthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour