TMPRSS15 antibody (Cleaved-Ile785, Light Chain)

Catalog No. ABIN8125349

This Rabbit Polyclonal antibody specifically detects TMPRSS15 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TMPRSS15 antibody (Cleaved-Ile785, Light Chain) (ABIN8125349)

Target: TMPRSS15 (Transmembrane Protease, serine 15 (TMPRSS15))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS15 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-TMPRSS15 Antibody

Binding Specificity: Cleaved-Ile785, Light Chain

Purpose: ENTK (light chain, Cleaved-Ile785) Antibody

Specificity: This antibody detects endogenous levels of Human ENTK (light chain, Cleaved-Ile785, protein was cleaved amino acid sequence between 785-786 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human ENTK (light chain, Cleaved-Ile785)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TMPRSS15

Target: TMPRSS15 (Transmembrane Protease, serine 15 (TMPRSS15))

Alternative Name: ENTK

Background:

Synonyms: Enteropeptidase (EC 3.4.21.9, Enterokinase, Serine protease 7, Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain, Enteropeptidase catalytic light chain]

Background: catalytic activity:Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.,disease:Defects in PRSS7 are a cause of enterokinase deficiency [MIM:226200], a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.,function:Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.,PTM:The chains are derived from a single precursor that is cleaved by a trypsin-like protease.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 MAM domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SEA domain.,similarity:Contains 1 SRCR domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 LDL-receptor class A domains.,subunit:Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.,tissue specificity:Intestinal brush border.,

Gene Name: TMPRSS15 ENTK PRSS7

Protein Name: ENTK (light chain, Cleaved-Ile785)

Gene ID: 5651

UniProt: P98073