TAL1/2 antibody (acLys221)

Catalog No. ABIN8125378

The Rabbit Polyclonal anti-TAL1/2 antibody (ABIN8125378) specifically detects TAL1/2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TAL1/2 antibody (acLys221) (ABIN8125378)

Target: TAL1/2 (TAL1_2) (Triacylglycerol Lipase-Like Protein (TAL1_2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1/2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TAL1/2 Antibody

Binding Specificity: acLys221

Purpose: TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) Antibody

Specificity: Acetyl-TAL1/2 (K221/K222/K36/K37) Polyclonal Antibody detects endogenous levels of TAL1/2 around the acetylation site of K221 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TAL1/2

Target: TAL1/2 (TAL1_2) (Triacylglycerol Lipase-Like Protein (TAL1_2))

Alternative Name: TAL1/2

Background:

Synonyms: TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5, TAL2, BHLHA19, T-cell acute lymphocytic leukemia protein 2, TAL-2, Class A basic helix-loop-helix protein 19, bHLHa19

Background: alternative products:The splicing pattern is cell-lineage dependent,disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1,14)(p32,q11) with T-cell receptor alpha chain (TCRA) genes.,domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.,function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.,PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.,PTM:Ubiquitinated, subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.,tissue specificity:Leukemic stem cell.,

Gene Name: TAL1/TAL2

Protein Name: T-cell acute lymphocytic leukemia protein 1 homolog/T-cell acute lymphocytic leukemia protein 2

Gene ID: 6886

UniProt: P17542