UBE3C antibody

Catalog No. ABIN8125546

The Rabbit Polyclonal anti-UBE3C antibody (ABIN8125546) specifically detects UBE3C in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for UBE3C antibody (ABIN8125546)

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE3C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UBE3C Antibody

Purpose: UBE3C Antibody

Specificity: UBE3C Polyclonal Antibody detects endogenous levels of UBE3C protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human UBE3C.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for UBE3C

Target: UBE3C (Ubiquitin Protein Ligase E3C (UBE3C))

Alternative Name: UBE3C

Background:

Synonyms: UBE3C, KIAA0010, KIAA10, Ubiquitin-protein ligase E3C, HectH2

Background: function:E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification, protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 IQ domain.,subunit:Interacts with 26S proteasomes. Binds CAND2.,tissue specificity:Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.,

Gene Name: UBE3C

Protein Name: Ubiquitin-protein ligase E3C

Gene ID: 148581

UniProt: Q15386