Vitamin D Receptor antibody (AA 150-250)

Catalog No. ABIN8125720

The Mouse Monoclonal anti-Vitamin D Receptor antibody (Clone AB2465) (ABIN8125720) specifically detects Vitamin D Receptor in WB, ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for Vitamin D Receptor antibody (AA 150-250) (ABIN8125720)

Target: Vitamin D Receptor (VDR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Vitamin D Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: AB2465

Product Details anti-Vitamin D Receptor Antibody

Binding Specificity: AA 150-250

Purpose: Vitamin D Receptor mouse mAb

Specificity: This antibody detects endogenous levels of Vitamin D Receptor protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 150 - 250 of the human Vitamin D Receptor protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Alternative Name: Vitamin D Receptor

Target Type: Chemical

Background:

Synonyms: Vitamin D3 receptor, VDR, 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, NR1I1

Background: vitamin D (1, 25-dihydroxyvitamin D3) receptor (VDR) Homo sapiens This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],

Gene Name: VDR

Protein Name: Vitamin D Receptor

Gene ID: 7421

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway