PROC antibody (Cleaved-Leu179, Light Chain)

Catalog No. ABIN8125721

This Rabbit Polyclonal antibody specifically detects PROC in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PROC antibody (Cleaved-Leu179, Light Chain) (ABIN8125721)

Target: PROC (Vitamin K-dependent protein C (PROC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PROC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PROC Antibody

Binding Specificity: Cleaved-Leu179, Light Chain

Purpose: PROC (light chain, Cleaved-Leu179) Antibody

Specificity: This antibody detects endogenous levels of Human PROC (light chain, Cleaved-Leu179, protein was cleaved amino acid sequence between 179-180 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human PROC (light chain, Cleaved-Leu179)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Alternative Name: PROC

Background:

Synonyms: Vitamin K-dependent protein C (EC 3.4.21.69, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide]

Background: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009],

Gene Name: PROC

Protein Name: PROC (light chain, Cleaved-Leu179)

Gene ID: 5624

UniProt: P04070