ZBTB33 antibody (AA 100-180)

Catalog No. ABIN8125797

The Rabbit Polyclonal anti-ZBTB33 antibody is suitable to detect ZBTB33 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for ZBTB33 antibody (AA 100-180) (ABIN8125797)

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ZBTB33 Antibody

Binding Specificity: AA 100-180

Purpose: KAISO Antibody

Specificity: KAISO Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 100-180

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ZBTB33

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Alternative Name: KAISO

Background:

Background: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor

Gene Name: ZBTB33 KAISO ZNF348

Protein Name: Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)

Gene ID: 10009

UniProt: Q86T24