HLTF antibody (AA 201-300) (Biotin)

Catalog No. ABIN762538

This Rabbit Polyclonal antibody specifically detects HLTF in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for HLTF antibody (AA 201-300) (Biotin) (ABIN762538)

Target: HLTF (Helicase-Like Transcription Factor (HLTF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLTF antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-HLTF Antibody (Biotin)

Binding Specificity: AA 201-300

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HLTF.

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HLTF

Target: HLTF (Helicase-Like Transcription Factor (HLTF))

Alternative Name: HLTF

Background:

Synonyms: DNA-binding protein/plasminogen activator inhibitor 1 regulator, Helicase like transcription factor, Helicase-like transcription factor, HIP116, HIP116A, HLTF 1, HLTF, HLTF_HUMAN, HLTF1, p113, RING finger protein 80, RNF80, SMARC A3, SMARCA 3, SMARCA3, SNF2-like 3, SNF2L3, Sucrose nonfermenting protein 2 like 3, Sucrose nonfermenting protein 2-like 3, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, ZBU 1, ZBU1.

Background: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity, This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

Gene ID: 6596