HCV NS5 antibody (N-Term)

Catalog No. ABIN781783

This Mouse Monoclonal antibody specifically detects HCV NS5 in EIA, IP and Func. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for HCV NS5 antibody (N-Term) (ABIN781783)

Target: HCV NS5 (Hepatitis C Virus NS5 (HCV NS5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HCV NS5 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Functional Studies (Func)

Clone: 8B2

Product Details anti-HCV NS5 Antibody

Binding Specificity: AA 1-19, N-Term

Purification: Protein G affinity chromatography

Immunogen: Recombinant Hepatitis C Virus nonstructural protein 5B (NS5B) RNAdependent RNA polymerase (RdRp)

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliquots) at -20 to -70 °C.

References for anti-HCV NS5 antibody (ABIN781783)

Nikonov, Juronen, Ustav: "Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase." in: The Journal of biological chemistry, Vol. 283, Issue 35, pp. 24089-102, (2008) (PubMed).

Target Details for HCV NS5

Target: HCV NS5 (Hepatitis C Virus NS5 (HCV NS5))

Alternative Name: HCV NS5

Target Type: Viral Protein

Background: Non-structural protein 5B (NS5B) represents the RNA-dependent RNA polymerase (RdRp) of Hepatitis C Virus, which is a small positive strand RNA virus in the family Flaviviridae. HCV is a major causative agent of acute and chronic hepatitis, hepatocellular carcinoma and liver cirrhosis. The single subunit RNA-dependent RNA polymerase is absolutely essential for the viral replication.Synonyms: Hepatitis C Virus, RNA-directed RNA polymerase NS5B