LRRFIP2 antibody (C-Term)

Catalog No. ABIN783417

Product Details anti-LRRFIP2 Antibody

Target: LRRFIP2 (Leucine Rich Repeat (In FLII) Interacting Protein 2 (LRRFIP2))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRFIP2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects LRRFIP2 at C-term. Three isoforms of LRRFIP2 are known to exist, this antibody will recognize all three. LRRFIP2 antibody is predicted to not cross-react with other LRRFIP family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the carboxy terminus of human LRRFIP2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for LRRFIP2

Target: LRRFIP2 (Leucine Rich Repeat (In FLII) Interacting Protein 2 (LRRFIP2))

Alternative Name: LRRFIP2 (LRRFIP2 Products)

Synonyms: HUFI-2 antibody, 5133400F20Rik antibody, AI850587 antibody, wu:fj34c02 antibody, zgc:113956 antibody, zgc:63771 antibody, LRR binding FLII interacting protein 2 antibody, leucine rich repeat (in FLII) interacting protein 2 antibody, leucine rich repeat (in FLII) interacting protein 2 L homeolog antibody, LRRFIP2 antibody, Lrrfip2 antibody, lrrfip2 antibody, lrrfip2.L antibody

Background: The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of b-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kB during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.Synonyms: LRR FLII-interacting protein 2, Leucine-rich repeat flightless-interacting protein 2

Gene ID: 9209

NCBI Accession: NP_001127841

UniProt: Q9Y608