SIK1 antibody (Center)

Catalog No. ABIN783464

Product Details anti-SIK1 Antibody

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SIK1 at Center. Two isoforms of SIK1 are known to exist, this antibody will detect both isoforms. SIK1 antibody is predicted to not cross-react with other SIK protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the center of human SIK1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

References for anti-SIK1 antibody (ABIN783464)

Chen, Shen, Wu, Hua, Kuang, Li, Peng: "CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 13725-38, (2016) (PubMed).

Target Details for SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Alternative Name: SIK1 (SIK1 Products)

Background: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.Synonyms: SIK, SIK-1, SNF1LK, Salt-inducible protein kinase 1, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SNF1-like kinase 1

Gene ID: 150094

NCBI Accession: NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process