LCMT2 antibody (N-Term)

Catalog No. ABIN783492

The Rabbit Polyclonal anti-LCMT2 antibody (ABIN783492) specifically detects LCMT2 in WB and EIA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for LCMT2 antibody (N-Term) (ABIN783492)

Target: LCMT2 (Leucine Carboxyl Methyltransferase 2 (LCMT2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCMT2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-LCMT2 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects LCMT2 at N-term. TYW4 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW4 are known to exist, this antibody will detect only the long isoform.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human TYW4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for LCMT2

Target: LCMT2 (Leucine Carboxyl Methyltransferase 2 (LCMT2))

Alternative Name: LCMT2

Background: TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.Synonyms: KIAA0547, Leucine carboxyl methyltransferase 2, TYW4, p21WAF1/CIP1 promoter-interacting protein, tRNA wybutosine-synthesizing protein 4 homolog, tRNA yW-synthesizing protein 4 homolog

Gene ID: 9836

NCBI Accession: NP_055608

UniProt: O60294