AP3S1 antibody (Center)

Catalog No. ABIN783504

Product Details anti-AP3S1 Antibody

Target: AP3S1 (Adaptor-Related Protein Complex 3, sigma 1 Subunit (AP3S1))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AP3S1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: At least three isoforms of AP3S1 are known to exist, this antibody will detect the two larger isoforms. AP3S1 antibody is predicted to not cross-react with other AP3 protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: Raised against a 19 amino acid peptide near the center of human AP3S1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for AP3S1

Target: AP3S1 (Adaptor-Related Protein Complex 3, sigma 1 Subunit (AP3S1))

Alternative Name: AP3 Complex Subunit sigma-1 (AP3S1 Products)

Synonyms: CLAPS3 antibody, Sigma3A antibody, [s]3A antibody, adaptor related protein complex 3 sigma 1 subunit antibody, adaptor-related protein complex 3, sigma 1 subunit antibody, adaptor related protein complex 3 sigma 1 subunit S homeolog antibody, AP3S1 antibody, Ap3s1 antibody, ap3s1.S antibody

Background: AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3 is an heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). AP3S1 Interacts with AGAP1 and may play an important role in carcinoma.Synonyms: AP-3 complex sigma-3A subunit, AP3S1, Adapter-related protein complex 3 sigma-1 subunit, CLAPS3, Clathrin-associated assembly/adapter protein, Sigma 3A Adaptin, Sigma-3A-adaptin, Sigma-adaptin 3a, small 3

Gene ID: 1176

NCBI Accession: NP_001275

UniProt: Q92572