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CMYA5 antibody (C-Term)

CMYA5 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783522
  • Target See all CMYA5 products
    CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
    Binding Specificity
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 1
    Rabbit
    Clonality
    • 1
    Polyclonal
    Conjugate
    • 1
    This CMYA5 antibody is un-conjugated
    Application
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Myospryn at C-term. SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    18 amino acid peptide near the carboxy terminus of human SPRYD2
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
    Alternative Name
    Myospryn (CMYA5 Products)
    Synonyms
    cmya5l antibody, DKFZp469P2126 antibody, C5orf10 antibody, SPRYD2 antibody, TRIM76 antibody, 2310076E16Rik antibody, 2310076E21Rik antibody, AA420382 antibody, AI504003 antibody, Srfsd antibody, Tims antibody, sr553 antibody, cardiomyopathy associated 5 antibody, CMYA5 antibody, cmya5 antibody, Cmya5 antibody
    Background
    SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.Synonyms: C5orf10, CMYA5, Cardiomyopathy-associated protein 5, DTNBP2, Dystrobrevin-binding protein 2, Genethonin-3, SPRY domain-containing protein 2, SPRYD2, TRIM76, Tripartite motif-containing protein 76
    Gene ID
    202333
    NCBI Accession
    NP_705838
    UniProt
    Q8N3K9
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