SPTLC2 antibody (C-Term)

Catalog No. ABIN783536

The Rabbit Polyclonal anti-SPTLC2 antibody is suitable to detect SPTLC2 in samples from Human, Mouse and Rat. It has been validated for WB, IF, IHC (p) and EIA.

Quick Overview for SPTLC2 antibody (C-Term) (ABIN783536)

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTLC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-SPTLC2 Antibody

Binding Specificity: C-Term

Specificity: This antibody recognizes Human SPTLC2. At least three isoforms of SPT2 are known to exist, this antibody will not detect isoform b. SPT2 antibody is predicted to not cross-react with SPT1.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.02 % Sodium Azide

Target Details for SPTLC2

Target: SPTLC2 (serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))

Alternative Name: SPTLC2

Background: SPTLC2 is a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.Synonyms: KIAA0526, LCB 2, LCB2, LCB2a, Long chain base biosynthesis protein 2, SPT 2, SPT2, Serine palmitoyltransferase 2, Serine-palmitoyl-CoA transferase 2

Gene ID: 9517

NCBI Accession: NP_004854

UniProt: O15270