FRMPD2 antibody (N-Term)

Catalog No. ABIN783582

This anti-FRMPD2 antibody is a Rabbit Polyclonal antibody detecting FRMPD2 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for FRMPD2 antibody (N-Term) (ABIN783582)

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRMPD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-FRMPD2 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the amino terminus of human FRMPD2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for FRMPD2

Target: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Alternative Name: FRMPD2

Background: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.Synonyms: FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4, PDZ domain-containing protein 5C, PDZD5C, PDZK4, PDZK5C

Gene ID: 143162

NCBI Accession: NP_001018081

UniProt: Q68DX3

Pathways: Cell-Cell Junction Organization