SIRT7 antibody (N-Term)

Catalog No. ABIN783618

The Chicken Polyclonal anti-SIRT7 antibody (ABIN783618) specifically detects SIRT7 in WB and EIA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for SIRT7 antibody (N-Term) (ABIN783618)

Target: SIRT7 (Sirtuin 7 (SIRT7))

Reactivity: Human, Rat, Mouse

Host: Chicken

Clonality: Polyclonal

Conjugate: This SIRT7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SIRT7 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human SIRT7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SIRT7

Target: SIRT7 (Sirtuin 7 (SIRT7))

Alternative Name: SIRT7

Background: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT7 is a nucleolar protein that positively regulates RNA polymerase I transcription and has been postulated to enable cells to sustain critical functions by inhibiting cell growth under severe stress conditions.Synonyms: NAD-dependent deacetylase sirtuin-7, S.cerevisiae, SIR2-like protein 7, SIR2L7, SIRT-7, homolog) 7, sirtuin (silent mating type information regulation 2, sirtuin 7, sirtuin type 7, sirtuin-7

Gene ID: 51547

NCBI Accession: NP_057622

UniProt: Q9NRC8