NLRP4 antibody (Center)

Catalog No. ABIN783705

The Rabbit Polyclonal anti-NLRP4 antibody (ABIN783705) specifically detects NLRP4 in WB and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for NLRP4 antibody (Center) (ABIN783705)

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-NLRP4 Antibody

Binding Specificity: Center

Specificity: This antibody detects NALP4 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the center of human NALP4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Alternative Name: NALP4

Background: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity.Synonyms: LRR and PYD domains-containing protein 4, NACHT, NLRP4, PAN2, PYPAF4, RNH2

Gene ID: 147945

NCBI Accession: NP_604393

UniProt: Q96MN2

Pathways: Inflammasome