NLRP7 antibody (N-Term)

Catalog No. ABIN783711

This anti-NLRP7 antibody is a Rabbit Polyclonal antibody detecting NLRP7 in WB and EIA. Suitable for Human.

Quick Overview for NLRP7 antibody (N-Term) (ABIN783711)

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-NLRP7 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects NLRP7 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of human NALP7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for NLRP7

Target: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Alternative Name: NLRP7

Background: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.Synonyms: LRR and PYD domains-containing protein 7, NALP7, NOD12, Nucleotide-binding oligomerization domain protein 12, PYPAF3, PYRIN-containing APAF1-like protein 3

Gene ID: 199713

NCBI Accession: NP_001120727

UniProt: Q8WX94

Pathways: Inflammasome