CXXC Finger Protein 4 (CXXC4) (N-Term) antibody

Details for Product No. ABIN783773
Antigen
Epitope
N-Term
16
8
8
8
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
40
17
6
2
2
2
2
2
1
1
Host
Rabbit
33
7
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
31
28
25
15
5
2
1
1
Options
Immunogen 18 amino acid peptide near the amino terminus of human CXXC4
Specificity This antibody detects CXXC4 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography purified via peptide column
Antigen
Alternative Name CXXC4 (CXXC4 Antibody Abstract)
Background CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
Gene ID 80319
NCBI Accession NP_079488
UniProt Q9H2H0
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Image no. 1 for anti-CXXC Finger Protein 4 (CXXC4) (N-Term) antibody (ABIN783773) Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ...