CXXC4 antibody (N-Term)

Catalog No. ABIN783773

The Rabbit Polyclonal anti-CXXC4 antibody is suitable to detect CXXC4 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for CXXC4 antibody (N-Term) (ABIN783773)

Target: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXXC4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CXXC4 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects CXXC4 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of human CXXC4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for CXXC4

Target: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Alternative Name: CXXC4

Background: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein

Gene ID: 80319

NCBI Accession: NP_079488

UniProt: Q9H2H0