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TMEM59 antibody (N-Term)
TMEM59
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TMEM59 Antibody
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Target
See all TMEM59 Antibodies
TMEM59
(Transmembrane Protein 59 (TMEM59))
Binding Specificity
All epitopes for TMEM59 antibodies
N-Term
Reactivity
All reactivities for TMEM59 antibodies
Human
Host
All hosts for TMEM59 antibodies
Rabbit
Clonality
All clonalities for TMEM59 antibodies
Polyclonal
Conjugate
All conjugates for TMEM59 antibodies
This TMEM59 antibody is un-conjugated
Application
All applications for TMEM59 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects TMEM59 at N-term.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Affinity chromatography purified via peptide column
Immunogen
16 amino acid peptide near amino terminus of human TMEM59
Top Product
Discover our top product TMEM59 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Target Details for TMEM59
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Target
TMEM59
(Transmembrane Protein 59 (TMEM59))
Alternative Name
TMEM59 (TMEM59 Products )
Synonyms
Tmem59 antibody, C1orf8 antibody, HSPC001 antibody, 1110001M20Rik antibody, 3110046P06Rik antibody, AI256529 antibody, D4Ertd20e antibody, MTDCF1 antibody, ORF18 antibody, transmembrane protein 59 antibody, tmem59 antibody, Tmem59 antibody, TMEM59 antibody
Background
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.Synonyms: C1orf8, HSPC001, Liver membrane-bound protein, Transmembrane protein 59
Gene ID
9528
NCBI Accession
NP_004863
UniProt
Q9BXS4
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