TLR3 antibody

Catalog No. ABIN783847

This Goat Polyclonal antibody specifically detects TLR3 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TLR3 antibody (ABIN783847)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human, Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TLR3 Antibody

Specificity: This antibody detects ~103 kDa of TLR3.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography

Immunogen: Synthetic peptide surrounding amino acid 805 of mouse TLR3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, containing 30 % clycerol, 0.5 % BSA, and 0.1 %thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C.

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: CD283 / TLR3

Background: To date, at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA, induces the activation of NF-kB, through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). Similar to several other members of the TLR family, TLR3 has been reported to be expressed at a very low level on the surface of human fibroblast cell lines.Synonyms: Toll-like receptor 3

Gene ID: 7098

NCBI Accession: NP_003256

UniProt: O15455

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades