ITIH4 antibody (C-Term)

Catalog No. ABIN783974

The Goat Polyclonal anti-ITIH4 antibody is suitable to detect ITIH4 in samples from Human. It has been validated for WB, IHC (p) and EIA.

Quick Overview for ITIH4 antibody (C-Term) (ABIN783974)

Target: ITIH4 (Inter alpha Globulin Inhibitor H4 (ITIH4))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This ITIH4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-ITIH4 Antibody

Binding Specificity: AA 890-903, C-Term

Sequence: C-SDDGRRTLRV QGND

Specificity: This antibody is expected to recognize both reported isoforms (NP_002209.2, NP_001159921.1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_002209.2 and NP_001159921.1. Genename: ITIH4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ITIH4

Target: ITIH4 (Inter alpha Globulin Inhibitor H4 (ITIH4))

Alternative Name: ITIH4

Background: The inter-a-trypsin inhibitor (ITI, IaI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family, it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.Synonyms: Gp120, IHRP, ITI heavy chain H4, ITI-HC4, ITIHL1, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, Inter-alpha-trypsin inhibitor heavy chain H4, PK120, Plasma kallikrein sensitive glycoprotein 120

Gene ID: 216

NCBI Accession: NP_002209

Pathways: Glycosaminoglycan Metabolic Process