Clvs1/2 antibody (C-Term)

Catalog No. ABIN784598

The Rabbit Polyclonal anti-Clvs1/2 antibody is suitable to detect Clvs1/2 in samples from Human, Mouse and Rat. It has been validated for IF and WB.

Quick Overview for Clvs1/2 antibody (C-Term) (ABIN784598)

Target: Clvs1/2 (Clavesin 1/2 (Clvs1/2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Application: Immunofluorescence (IF), Western Blotting (WB)

Product Details anti-Clvs1/2 Antibody

Binding Specificity: C-Term

Specificity: Specific for the ~35 kDa Clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are Clavesin 1 and 2, respectively.

Cross-Reactivity (Details): Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogen: Synthetic peptide KLH-conjugated corresponding to amino acid residues from the C-terminal region of Rat Clavesin-1. Genename: CLVS1/2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C.

Target Details for Clvs1/2

Target: Clvs1/2 (Clavesin 1/2 (Clvs1/2))

Background: Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).Synonyms: C6orf212, C6orf213, CLVS1, CLVS2, CRALBPL, Cellular retinaldehyde-binding protein-like, RLBP1L1, RLBP1L2, Retinaldehyde-binding protein 1-like 1/2

Gene ID: 366311

NCBI Accession: NP_001102439