GRM7 antibody (pSer862)

Catalog No. ABIN784604

The Rabbit Polyclonal anti-GRM7 antibody has been validated for IHC (fro). It is suitable to detect GRM7 in samples from Human, Rat, Mouse, Dog, Cow, Zebrafish (Danio rerio) and Non-Human Primate.

Quick Overview for GRM7 antibody (pSer862) (ABIN784604)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reactivity: Human, Rat, Mouse, Dog, Cow, Zebrafish (Danio rerio), Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM7 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GRM7 Antibody

Binding Specificity: pSer862

Specificity: Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Canine, Human, non-Human Primate and Zebrafish.
Species reactivity (tested):Mouse and Rat.

Purification: Affinity Chromatography.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser862 of Rat mGluR7.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Target Details for GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Alternative Name: mGluR7 / GRM7

Background: Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).Synonyms: GPRC1G, MGLUR7, Metabotropic glutamate receptor 7

Gene ID: 81672

NCBI Accession: NP_112302

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour