GABBR2 antibody (pSer783) (Biotin)

Catalog No. ABIN800855

The Rabbit Polyclonal anti-GABBR2 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect GABBR2 in samples from Human.

Quick Overview for GABBR2 antibody (pSer783) (Biotin) (ABIN800855)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GABBR2 Antibody (Biotin)

Binding Specificity: pSer783

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human GABBR2 around the phosphorylation site of Ser783

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABBR2

Background:

Synonyms: GABA B Receptor 2 phospho S783, p-GABA B Receptor 2 phospho S783, GABBR2 Ser783, p-GABBR2 Ser783, GABBR2, GB2, G protein coupled receptor 51, G-protein coupled receptor 51, GAB B R2, GABA B R2, GABA B receptor 2, GABA B RECEPTOR, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABA[[B]]R2, GABAB R2, GABABR 2, GABABR2, GABB R2, GABBR 2, Gabbr2, GABR2_HUMAN, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid B receptor 2, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid type B receptor subunit 2, Gamma-aminobutyric acid type B receptor subunit 2, Gb 2, Gb2, GH07312, GPR 51, GPR51, GPRC 3B, GPRC3B, HG 20, HG20, HRIHFB2099, Metabotropic GABA B receptor subtype 2, OTTHUMP00000021776, OTTHUMP00000063797, R2 SUBUNIT, BcDNA:GH07312, CG6706, CT20836, D GABA[[B]]R2, D Gaba2, FLJ36928.

Background: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Gene ID: 9568

Pathways: cAMP Metabolic Process