EGFR antibody (C-Term)

Catalog No. ABIN870533

The Rabbit Monoclonal anti-EGFR antibody has been validated for IHC (p). It is suitable to detect EGFR in samples from Human.

Quick Overview for EGFR antibody (C-Term) (ABIN870533)

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This EGFR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: A20-E

Product Details anti-EGFR Antibody

Binding Specificity: AA 1120-1135, C-Term

Purpose: Anti-EGFR

Specificity: EGFR

Immunogen: Peptide derived from C-terminal region of human epidermal growth factor receptor (EGFR). Antibody recognizes the epitope between Ser1120 - Asn1135.

Isotype: IgG

Application Details

Application Notes: 1:100 - 200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: +2 °C to +8 °C

Target Details for EGFR

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Alternative Name: EGFR

Background: Epidermal Growth Factor Receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, colon and in squamous cell carcinoma.

UniProt: P00533

Pathways: NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins