CEND1 antibody (AA 4-100)

Catalog No. ABIN872436

The Rabbit Polyclonal anti-CEND1 antibody (ABIN872436) specifically detects CEND1 in WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). The antibody is reactive with Mouse and Rat samples.

Quick Overview for CEND1 antibody (AA 4-100) (ABIN872436)

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEND1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CEND1 Antibody

Binding Specificity: AA 4-100

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CEND1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CEND1

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Alternative Name: CEND1

Background:

Synonyms: BM88, BM88 antigen, Cell cycle exit and neuronal dferentiation 1, Cell cycle exit and neuronal dferentiation protein 1, FLJ90066, MGC34326, CEND_HUMAN

Background: BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Gene ID: 51286