Adrenomedullin 2 antibody (AA 121-180)

Catalog No. ABIN872804

The Rabbit Polyclonal anti-Adrenomedullin 2 antibody is suitable to detect Adrenomedullin 2 in samples from Human. It has been validated for IF (cc), IF (p), IHC (fro) and IHC (p).

Quick Overview for Adrenomedullin 2 antibody (AA 121-180) (ABIN872804)

Target: Adrenomedullin 2 (ADM2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adrenomedullin 2 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Adrenomedullin 2 Antibody

Binding Specificity: AA 121-180

Purpose: AIFM2 Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AMID/AIFM2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Adrenomedullin 2

Target: Adrenomedullin 2 (ADM2)

Alternative Name: AM2

Background:

Synonyms: am2, AM2_HUMAN, AMID, Apoptosis inducing factor A homologous mitochondrion associated inducer of death, Apoptosis inducing factor A like mitochondrion associated inducer of death, Apoptosis inducing factor mitochondrion associated 2, Apoptosis-inducing factor 2, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Cys51Stop, p53 responsive gene 3 p53 tumor suppressor p53-responsive gene 3 protein PRG3 TRP53 Tumor protein p53.

Background: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.Tissue specificity: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.

Gene ID: 84883

Pathways: Hormone Activity, Feeding Behaviour