FRS2 antibody (AA 221-320)

Catalog No. ABIN872985

The Rabbit Polyclonal anti-FRS2 antibody (ABIN872985) specifically detects FRS2 in WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Rat samples.

Quick Overview for FRS2 antibody (AA 221-320) (ABIN872985)

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FRS2 Antibody

Binding Specificity: AA 221-320

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FRS2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2

Background:

Synonyms: FGFR signaling adaptor SNT, FGFR signalling adaptor, FGFR substrate 2, FGFR-signaling adaptor SNT, Fibroblast Growth Factor Receptor Substrate 2, FRS 2, FRS2, FRS2_HUMAN, FRS2A, FRS2alpha, SNT 1, SNT, SNT-1, SNT1, Suc 1 Associated Neurotrophic Factor Target, Suc1 associated neurotrophic factor target 1, Suc1-associated neurotrophic factor target 1.

Background: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.Tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Gene ID: 10818

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2