TACC1 antibody (AA 588-680)

Catalog No. ABIN873222

The Rabbit Polyclonal anti-TACC1 antibody (ABIN873222) specifically detects TACC1 in IHC (p), IF (cc), IF (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for TACC1 antibody (AA 588-680) (ABIN873222)

Target: TACC1 (Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TACC1 Antibody

Binding Specificity: AA 588-680

Purpose: TACC1 Polyclonal Antibody

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TACC1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TACC1

Target: TACC1 (Transforming, Acidic Coiled-Coil Containing Protein 1 (TACC1))

Alternative Name: TACC1

Background:

Synonyms: Ga 55, Ga55, Gastric cancer antigen Ga 55, Gastric cancer antigen Ga55, KIAA1103, TACC 1, Taxin 1, Taxin1, transforming acidic coiled coil containing protein 1, DKFZp686K18126, TACC1_HUMAN.

Background: TACC1 is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15 % of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner

Gene ID: 6867