Tryptophan Hydroxylase 1 antibody (pSer260) (AbBy Fluor® 647)

Catalog No. ABIN875156

The Rabbit Polyclonal anti-Tryptophan Hydroxylase 1 antibody has been validated for WB. It is suitable to detect Tryptophan Hydroxylase 1 in samples from Human, Mouse and Rat.

Quick Overview for Tryptophan Hydroxylase 1 antibody (pSer260) (AbBy Fluor® 647) (ABIN875156)

Target: Tryptophan Hydroxylase 1 (TPH1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tryptophan Hydroxylase 1 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB)

Product Details anti-Tryptophan Hydroxylase 1 Antibody (AbBy Fluor® 647)

Binding Specificity: pSer260

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human TPH around the phosphorylation site of Ser260

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Tryptophan Hydroxylase 1

Target: Tryptophan Hydroxylase 1 (TPH1)

Alternative Name: Tph

Background:

Synonyms: Tph1phospho S260, TPH phospho Ser260, p-TPH Ser260, MGC119994, TPH 1, TPH, TPH1, TPRH, Tryptophan 5 hydroxylase 1, Tryptophan 5 monooxygenase 1, Tryptophan 5 monooxygenase, Tryptophan hydroxylase 1, Tryptophan 5-hydroxylase 1, TPH1_HUMAN.

Background: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

Gene ID: 7166

Pathways: Feeding Behaviour