APC1 antibody (pSer377) (AbBy Fluor® 647)

Catalog No. ABIN875848

This Rabbit Polyclonal antibody specifically detects APC1 in IF (cc) and IF (p). It exhibits reactivity toward Rat.

Quick Overview for APC1 antibody (pSer377) (AbBy Fluor® 647) (ABIN875848)

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC1 antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-APC1 Antibody (AbBy Fluor® 647)

Binding Specificity: pSer377

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ANAPC1 around the phosphorylation site of Ser377

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APC1

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Alternative Name: APC1

Background:

Synonyms: Apc1 phospho S377, p-Apc1 phospho S377, ANAPC1Ser377, ANAPC 1, ANAPC1, Anaphase promoting complex subunit 1, anaphase-promoting complex 1 meiotic checkpoint regulator, Anaphase-promoting complex subunit 1, Apc 1, APC1, APC1_HUMAN, Cyclosome subunit 1, MCPR, Meiotic checkpoint regulator, Mitotic checkpoint regulator, Protein Tsg 24, Protein Tsg24, Testis-specic gene 24 protein, TSG 24, TSG24.

Background: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

Gene ID: 64682