APC1 antibody (pSer688)

Catalog No. ABIN1531641

The Rabbit Polyclonal anti-APC1 antibody (ABIN1531641) specifically detects APC1 in ELISA, IHC, IF and WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for APC1 antibody (pSer688) (ABIN1531641)

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB)

Product Details anti-APC1 Antibody

Binding Specificity: AA 654-703, pSer688

Purpose: APC1 (phospho Ser688) Antibody

Specificity: Phospho-APC1 (S688) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S688.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human APC1 around the phosphorylation site of Ser688. AA range:654-703

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for APC1

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Alternative Name: APC1

Background:

Synonyms: ANAPC1, TSG24, Anaphase-promoting complex subunit 1, APC1, Cyclosome subunit 1, Mitotic checkpoint regulator, Testis-specific gene 24 protein

Background: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011],

Gene Name: ANAPC1

Protein Name: Anaphase-promoting complex subunit 1

Molecular Weight: 216 kDa

Gene ID: 64682

OMIM: 608473

UniProt: Q9H1A4