Cytokeratin 18 antibody (pSer60) (AbBy Fluor® 350)

Catalog No. ABIN876956

The Rabbit Polyclonal anti-Cytokeratin 18 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect Cytokeratin 18 in samples from Human, Mouse and Rat.

Quick Overview for Cytokeratin 18 antibody (pSer60) (AbBy Fluor® 350) (ABIN876956)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytokeratin 18 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Cytokeratin 18 Antibody (AbBy Fluor® 350)

Binding Specificity: pSer60

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CK18 around the phosphorylation site of Ser60 [MG(p-S)GG]

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Alternative Name: CK18

Background:

Synonyms: Cytokeratin 18 phospho S60, p-Cytokeratin 18 phospho S60, Cell proliferation inducing gene 46 protein, Cell proliferation inducing protein 46, Cell proliferation-inducing gene 46 protein, CK 18, CK-18, CK18, CYK 18, CYK18, Cytokeratin 18, Cytokeratin endo B, Cytokeratin-18, Cytokeratin18, K 18, K18, K1C18_HUMAN, Keratin 18, Keratin D, Keratin type I cytoskeletal 18, keratin, type I cytoskeletal 18, Keratin-18, Keratin18, Kerd, KRT18.

Background: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Gene ID: 3875

Pathways: Apoptosis, Caspase Cascade in Apoptosis