LKB1 antibody (pThr189) (AbBy Fluor® 488)

Catalog No. ABIN877642

This Rabbit Polyclonal antibody specifically detects LKB1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for LKB1 antibody (pThr189) (AbBy Fluor® 488) (ABIN877642)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-LKB1 Antibody (AbBy Fluor® 488)

Binding Specificity: pThr189

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Thr189 [G(p-T)LK]

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: LKB1

Background:

Synonyms: LKB 1, LKB1, NY REN 19 antigen, Peutz Jeghers syndrome, PJS, Serine/Threonine Kinase 11, Serine/threonine protein kinase 11, Serine/threonine protein kinase LKB1, STK 11, STK11.

Background: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

Gene ID: 6794

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect