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Cortactin antibody (pThr466) (AbBy Fluor® 555)

CTTN Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 555

Catalog No. ABIN879742

Datasheet as PDF

Target See all Cortactin (CTTN) Antibodies

Cortactin (CTTN)
Binding Specificity
14

13

12

7

7

6

6

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr466
Reactivity
119

59

41

5

4

2

2

2

2

2

2

1

1

1
Human
Host
119

7

1
Rabbit
Compatible Secondaries
Clonality
111

16
Polyclonal
Conjugate
76

7

4

4

4

4

4

4

3

3

2

2

1

1

1

1

1

1

1

1

1

1
This Cortactin antibody is conjugated to AbBy Fluor® 555
Application
92

50

49

16

13

13

13

12

11

6

3

2

1

1

1

1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity

Human

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr466(YAp-TEA)

Isotype

IgG

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KO Validated CTTN Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) (AA 214-513) antibody
CTTN Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) antibody
CTTN Reactivity: Human WB, IHC, IF, IP Host: Rabbit Monoclonal unconjugated

anti-Cortactin (CTTN) (pTyr466) antibody
CTTN Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) antibody
CTTN Reactivity: Human WB, IHC, ELISA Host: Mouse Monoclonal 4C6 unconjugated

anti-Cortactin (CTTN) (AA 341-450) antibody
CTTN Reactivity: Human WB, ELISA, PLA Host: Mouse Monoclonal 2B5 unconjugated

anti-Cortactin (CTTN) (AA 1-509) antibody
CTTN Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) (AA 1-509) antibody
CTTN Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) (pTyr421) antibody
CTTN Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Cortactin (CTTN) (AA 273-302) antibody
CTTN Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB33698 unconjugated

Application Notes

IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date

12 months
Target

Cortactin (CTTN)

Alternative Name

Cortactin (CTTN Products)

Background

Synonyms: Amplaxin, CTTN, EMS 1, EMS1, Mammary tumor and squamous cell carcinoma associated, Oncogene EMS1, p80/85 src substrate, Src substrate cortactin, SRC8_HUMAN.
Background: Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino terminal tandem repeats of a unique 37 amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an alpha helical structure followed by a proline rich region. Between the proline rich region and the SH3 domain, there are a series of Src phosphorylation sites (Tyr421, Tyr470, and Tyr486). In vitro, cortactin binds to and cross links F actin into meshworks.

Gene ID

2017

Pathways

MAPK Signaling