ALAD antibody (AA 151-240) (Biotin)

Catalog No. ABIN882111

This anti-ALAD antibody is a Rabbit Polyclonal antibody detecting ALAD in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for ALAD antibody (AA 151-240) (Biotin) (ABIN882111)

Target: ALAD (Aminolevulinate Dehydratase (ALAD))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALAD antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ALAD Antibody (Biotin)

Binding Specificity: AA 151-240

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ALAD

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ALAD

Target: ALAD (Aminolevulinate Dehydratase (ALAD))

Alternative Name: ALAD

Background:

Synonyms: ALAD, ALADH, ALADR, Aminolevulinate dehydratase, Aminolevulinate, delta, dehydratase, Delta aminolevulinic acid dehydratase, Delta-aminolevulinic acid dehydratase, HEM2_HUMAN, Lv, PBGS, Porphobilinogen synthase.

Background: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.Involvement in disease:Defects in ALAD are the cause of acute hepatic porphyria (AHP). AHP is a form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralysis, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors.

Gene ID: 210

UniProt: P13716