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CDC14B antibody (AA 65-160) (FITC)

This Rabbit Polyclonal antibody specifically detects CDC14B in IF (cc) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN889459

Quick Overview for CDC14B antibody (AA 65-160) (FITC) (ABIN889459)

Target

See all CDC14B Antibodies
CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Reactivity

Human, Mouse, Rat

Host

  • 26
  • 4
Rabbit

Clonality

  • 30
Polyclonal

Conjugate

  • 11
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CDC14B antibody is conjugated to FITC

Application

  • 12
  • 12
  • 10
  • 6
  • 3
  • 3
  • 3
  • 2
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-160

    Cross-Reactivity

    Human, Mouse, Rat

    Predicted Reactivity

    Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CDC14B

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

    Alternative Name

    CDC14B

    Background

    Synonyms: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B

    Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

    Gene ID

    8555

    UniProt

    O60729
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