CDC14B antibody (AA 65-160) (FITC)
Quick Overview for CDC14B antibody (AA 65-160) (FITC) (ABIN889459)
Target
See all CDC14B AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 65-160
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Cross-Reactivity
- Human, Mouse, Rat
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Predicted Reactivity
- Rabbit
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human CDC14B
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Isotype
- IgG
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Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Expiry Date
- 12 months
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- CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))
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Alternative Name
- CDC14B
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Background
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Synonyms: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B
Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
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Gene ID
- 8555
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UniProt
- O60729
Target
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