CLEC5A antibody (AA 101-190) (AbBy Fluor® 647)

Catalog No. ABIN891259

This Rabbit Polyclonal antibody specifically detects CLEC5A in WB, FACS, IF (cc) and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for CLEC5A antibody (AA 101-190) (AbBy Fluor® 647) (ABIN891259)

Target: CLEC5A (C-Type Lectin Domain Family 5, Member A (CLEC5A))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLEC5A antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CLEC5A Antibody (AbBy Fluor® 647)

Binding Specificity: AA 101-190

Purpose: CLEC5A Polyclonal Antibody, AbBy Fluor-647 Conjugated

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CLEC5A

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLEC5A

Target: CLEC5A (C-Type Lectin Domain Family 5, Member A (CLEC5A))

Alternative Name: CLEC5A

Background:

Synonyms: Mdl1, Ly100, MDL-1, Clecsf5, C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1, Clec5a

Background: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release.

Gene ID: 23845

UniProt: Q9R007