CNIH2, CNIH3 (AA 25-120) antibody (Biotin)

Catalog No. ABIN891492

The Biotin-conjugated Rabbit Polyclonal anti-CNIH2, CNIH3 antibody (ABIN891492) specifically detects CNIH2, CNIH3 in WB, ELISA, IHC (fro) and IHC (p). The antibody is reactive with Rat samples.

Quick Overview for CNIH2, CNIH3 (AA 25-120) antibody (Biotin) (ABIN891492)

Target: CNIH2, CNIH3

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 25-120

Specificity: This antibody detects both CNIH2 and CNIH3 proteins

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CNIH2/CNIH3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details

Target: CNIH2, CNIH3

Alternative Name: CNIH2/3

Background:

Synonyms: Protein cornichon homolog 2, CNIH2, Cornichon family AMPA receptor auxiliary protein 2, Protein cornichon homolog 3, CNIH3, Cornichon family AMPA receptor auxiliary protein 3

Background: CNIH2 and CNIH3 regulate the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). They promote their targeting to the cell membrane and synapses and modulate their gating properties by regulating their rates of activation, deactivation and desensitization. CNIH2 also blocks CACNG8-mediated resensitization of AMPA receptors.

Gene ID: 254263, 149111

UniProt: Q6PI25, Q8TBE1