CPB2 antibody (AA 131-230) (AbBy Fluor® 647)

Catalog No. ABIN892103

The Rabbit Polyclonal anti-CPB2 antibody has been validated for IF (cc) and IF (p). It is suitable to detect CPB2 in samples from Human.

Quick Overview for CPB2 antibody (AA 131-230) (AbBy Fluor® 647) (ABIN892103)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPB2 antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CPB2 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 131-230

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CPB2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: CPB2

Background:

Synonyms: Carboxypeptidase B like protein, Carboxypeptidase U, CarboxypeptidaseB2, Carboxypeptidase B2, CarboxypeptidaseU, CP B2, CPB 2, CPB2, CPU, PCPB, Plasma carboxypeptidase B, Plasma carboxypeptidase B2, Procarboxypeptidase B, Procarboxypeptidase R, Procarboxypeptidase U, TAFI, Thrombin activable fibrinolysis inhibitor, Thrombin activatable fibrinolysis inhibitor.

Background: This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues, pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5-10 μg/mL. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.

Gene ID: 1361

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis