IKZF1 antibody (AA 251-360) (HRP)
Quick Overview for IKZF1 antibody (AA 251-360) (HRP) (ABIN901998)
Target
See all IKZF1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 251-360
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Cross-Reactivity
- Mouse
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Predicted Reactivity
- Human,Rat,Chicken
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human IKAROS
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Isotype
- IgG
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Application Notes
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Handling Advice
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Expiry Date
- 12 months
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- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
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Alternative Name
- IKAROS
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Background
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Synonyms: IKAROS family zinc finger 1 Ikaros, PRO0758, CLL associated antigen KW 6, DNA-binding protein Ikaros, hIk 1, hIk-1, IK1, Ikaros zinc finger protein, IKAROS, Ikaros family zinc finger protein 1, Ikzf1, IKZF1_HUMAN, LYF1, Lymphoid transcription factor LyF-1, zinc finger protein subfamily 1A 1, ZNFN1A1.
Background: Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs).Tissue specificity:Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
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Gene ID
- 10320
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Pathways
- Production of Molecular Mediator of Immune Response
Target
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